28 research outputs found
Visual Analysis of Hyperproperties for Understanding Model Checking Results
- Author
- Publication venue
- Publication date
- 23/10/2021
- Field of study
Model checkers provide algorithms for proving that a mathematical model of a system satisfies a given specification. In case of a violation, a counterexample that shows the erroneous behavior is returned. Understanding these counterexamples is challenging, especially for hyperproperty specifications, i.e., specifications that relate multiple executions of a system to each other. We aim to facilitate the visual analysis of such counterexamples through our HYPERVIS tool, which provides interactive visualizations of the given model, specification, and counterexample. Within an iterative and interdisciplinary design process, we developed visualization solutions that can effectively communicate the core aspects of the model checking result. Specifically, we introduce graphical representations of binary values for improving pattern recognition, color encoding for better indicating related aspects, visually enhanced textual descriptions, as well as extensive cross-view highlighting mechanisms. Further, through an underlying causal
analysis of the counterexample, we are also able to identify values that contributed to the violation and use this knowledge for both improved encoding and highlighting. Finally, the analyst can modify both the specification of the hyperproperty and the system directly within HYPERVIS and initiate the model checking of the new version. In combination, these features notably support the analyst in
understanding the error leading to the counterexample as well as iterating the provided system and specification. We ran multiple case studies with HYPERVIS and tested it with domain experts in qualitative feedback sessions. The participants’ positive feedback confirms the considerable improvement over the manual, text-based status quo and the value of the tool for explaining hyperproperties
Corporate Entrepreneurship:From Structures to Mindset
- Author
- A Whittle
- AH Ven Van de
- AJ Frederiks
- B Antoncic
- BB Lichtenstein
- C Noble
- CA O’Reilly III
- CB Flora
- CB Gibson
- CM Gaglio
- D Dimov
- DA Shepherd
- DF Kuratko
- DF Kuratko
- DJ Kelley
- DV Brazeal
- F Campos
- GC O’Connor
- GG Dess
- GR Mitchell
- GT Lumpkin
- H Laalo
- J Birkinshaw
- J Birkinshaw
- J Haynie
- JG Covin
- JM Howell
- JM Howell
- JM Howell
- JM Stopford
- JPC Rigtering
- JS Alvarez
- JS Hornsby
- JS Hornsby
- JS Hornsby
- KA Ericsson
- LP Kyrgidou
- ML Tushman
- MP Miles
- N Culkin
- NF Krueger
- NF Krueger
- NF Krueger
- O Belousova
- P Kesting
- P Sharma
- PH Phan
- PM Gollwitzer
- R Garud
- R Self Dennis
- RA Burgelman
- RA Burgelman
- RA Burgelman
- RD Hisrich
- RD Ireland
- RD Ireland
- RG McGrath
- RM Kanter
- S Ghoshal
- S Makimurto-Koivumaa
- S Patel
- S Robinson
- S Shane
- S Shane
- SA Zahra
- SMR Shams
- TA Björklund
- WB Gartner
- Y Sarason
- Z Simsek
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Corporate entrepreneurship dispersed throughout an organization and leveraging the entrepreneurial potential of all its employees bears significant benefits for those organizations that embrace it. However, it appears more difficult to instill and requires strong investment in the development of human capital and entrepreneurial mindset among the employees and across the organization. In this chapter, we discuss the essence of corporate entrepreneurship mindset and show that across an organization, there might be different entrepreneurial mindsets that correspond to different people, opportunities, and contexts. Although different, they all lead to enactment of entrepreneurial projects. This chapter, thus, contributes to the discussion regarding the nature of corporate entrepreneurial mindsets, and their development and stimulation within an organization, from both academic and practical view
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
- Author
- Aaronson Keith
- Abadier Rafik
- Abbasi Siddique A.
- Abdullah Shuaib
- Abelson Mark
- Abhayaratna Walter
- Ablasser Klemens
- Aboyans Victor
- Abo‐Auda Wael
- Abuannadi Mohammad
- Adams Kirkwood
- Adams Kirkwood F.
- Adhya Shaumik
- Adler Alexander
- Aggarwala Gaurav
- Agostoni Piergiuseppe
- Ahmad Saad
- Aiub Jorge Roberto
- Al Mohammad Abdallah
- Alharethi Rami
- Alieksieieva Liudmyla
- Almeida Filipa
- Almousalli Omar
- Amano Tetsuya
- Amanullah Aman
- Ambardekar Amrut
- Amerena John
- Anand Inder
- Anderson William
- Ando Kenji
- Andreka Peter
- Antalik Lubomir
- Aradi Daniel
- Araiza Raul Reyes
- Arbolishvili Georgy
- Ariani Mehrdad
- Arias‐Mendoza Alexandra
- Arora Raveen
- Arroyo Julian Alonso Coronel
- Artis Andre
- Asakura Masanori
- Asano Hiroshi
- Ashcom Thomas
- Aslam Shamaila
- Asubiaro Joshua
- Atherton John
- Avaca Horacio Alberto
- Babapulle Mohan
- Bacal Fernando
- Badak Ozer
- Badariene Jolita
- Badat Aysha
- Baker Mathue
- Balsam Pawel
- Banerji Sourin
- Barbarash Olga
- Barbetseas Ioannis
- Barr Craig
- Barros e Silva Pedro Gabriel Melo
- Barua Rajat
- Bauerlein Eugene Joseph
- Baweja Paramdeep
- Bednarkiewicz Zbigniew
- Beelen Driek
- Begg Alistair
- Bekar Lutfu
- Belenkiy Dmitriy
- Belohlavek Jan
- Beltrame John
- Berdague Philippe
- Berglund Stefan
- Berk Martin
- Berkowski Piotr
- Berra Fernando Colombo
- Bertolet Barry
- Besada Diego Alejandro
- Beug Daniel
- Bezzegh Katalin
- Bhagwat Ravi
- Bhargava Rakesh
- Biering‐Sørensen Tor
- Bilato Claudio
- Blicharski Tomasz
- Boccalandro Fernando
- Boehm Michael
- Boehmer John
- Bogaev Roberta
- Bolshakova Olga
- Boman Kurt
- Bonderman Diana
- Bonet Luis Almenar
- Bonfanti Alberto Cadena
- Bordonava Anselmo Paulino
- Bostick Brian
- Boswijk Dirk
- Bourgeois Ronald
- Bourhaial Hakima
- Bouza Manuel
- Braga Joao Carlos
- Brasca Daniela Garcia
- Brinkley Douglas
- Brito Dulce
- Brunetti Natale Daniele
- Bruno Marco Raul Litvak
- Bu Peili
- Burgess Lesley
- Busak Ladislav
- Buynak Robert
- Buysschaert Ian
- Bykov Alexander
- Böhm Michael
- Caccavo Alberto
- Canesin Manoel
- Cardona Jose
- Cardoso Juliano
- Carluccio Erberto
- Carrasco Jose Alfredo Pagola
- Carson Peter
- Castillo Armando Garcia
- Cavallini Claudio
- Cavusoglu Yuksel
- Cech Vladimir
- Celik Ahmet
- Celutkiene Jelena
- Cepelak Michal
- Cerci Rodrigo Julio
- Chandra Lokesh
- Chandrasekaran Badrinathan
- Chang David
- Chaves Renato
- Chehayeb Raja
- Cheirif Jorge
- Chen Guoqin
- Chen Jiyan
- Chmielak Zbigniew
- Chouchane Iman
- Chung Eugene
- Cid Maria Cristina Schnettler
- Civitello Andrew
- Clark Andrew
- Cleland John G.F.
- Clifford Piers
- Coletti Andrew
- Collins John
- Colque Roberto
- Constance Christian
- Contreras Johanna
- Corbalan Ramon
- Corbalan Ramon
- Correa Luis Eduardo Echeverria
- Corredor Miguel Alfredo Moncada
- Cosansu Kahraman
- Costa‐Vitali Atilio
- Cotarlan Vladimir
- Coufal Zdenek
- Cox Jeremy
- Crespo‐Leiro Maria G.
- Cruz Kimberly
- Cubero Javier Segovia
- Cui Hanbin
- Cymerman Krzysztof
- Dahlström Ulf
- Damy Thibaud
- Dauber Ira
- De Geeter Guillaume
- De los Rios Ibarra Manuel Odin
- De Pasquale Carmine
- Decoulx Eric
- Demir Mesut
- Desai Pratik
- Diaz Rafael
- Diaz Rafael
- Diaz Victor Alfonso Jimenez
- Dib Nabil
- Diez Mirta
- Dimov Bojidar
- Doblas Juan Jose Gomez
- Doi Masayuki
- Domae Hiroshi
- Donal Erwan
- Dong Yugang
- Donnelly Patrick
- Dorobantu Maria
- Dovgolis Svetlana
- Doyle Timothy
- Drexel Heinz
- Dronov Dmitry
- Droogne Walter
- Drozdz Jaroslaw
- Duarte Tatiana
- Duengen Hans‐Dirk
- Dujardin Karl
- Dupont Matthias
- Duran Ruben Omar Garcia
- Duzenli Mehmet
- Dzupina Andrej
- Eaton Charles
- Ebato Mio
- Ebelt Henning
- Eberly Arthur
- Ebner Christian
- Echeverria Correa Luis E.
- Elliott James
- Elmahi Einas
- Elvan Arif
- Esperon Guillermo Antonio Llamas
- Ezekowitz Justin
- Ezhov Marat
- Fang James
- Fang James C.
- Farris Neil
- Feitell Scott
- Felker G. Michael
- Fernandez Alberto
- Fernando Ronald
- Ferraz Almir
- Figal Domingo Andres Pascual
- Filho Otavio Coelho
- Filho Pedro Pimentel
- Filippatos Gerasimos
- Fisher Daniel
- Florea Viorel
- Flores Ana Maria De Leon
- Floresta Agata Marina
- Fonseca Candida
- Fonseca Cândida
- Forman Steven
- Forster Tamas
- Fortes Jose Augusto Ribas
- Fourie Nyda
- Franchi Francesco
- Frank Theodore
- Frankenstein Lutz
- Freire Ramon Bover
- Fremont Richard
- French John
- Friedman Keith
- Frigerio Maria
- Friz Hernan Emilio Francisco Polo
- Fu Xin
- Fucili Alessandro
- Fuente Galan Luis
- Fuente Ricardo Alfonso Leon
- Fujii Kenshi
- Fujii Shigeru
- Fujiwara Wakaya
- Fukuzawa Shigeru
- Fulop Peter
- Gabriel George
- Gajardo Victor Areli Saavedra
- Galinier Michel
- Ganeshram Vedampattu
- Ganji Jagadeesh
- Garrido Marcelo Alejandro
- Gass Alan
- Gaudet Daniel
- Geltman Edward
- Gemignani Anthony
- Genth‐Zotz Sabine
- Georges Jean‐Louis
- Giamouzis Grigorios
- Gianfagna Robert
- Giannetti Nadia
- Gilmore Richard
- Giorgeto Flavio Eduardo
- Giraldo Clara Ines Saldarriaga
- Giuca Alina
- Giudici Vittorio
- Glover Jason
- Gogia Harinder
- Gohara Seiichiro
- Gola Zbigniew
- Goloshchekin Boris
- Goncalvesova Eva
- Goncalvesova Eva
- Goncharov Ivan
- Gonsorcik Jozef
- Gonzalez Ricardo Garcia
- Gonzalez Salvador Leon
- Gordon Brian
- Gorodeski Eiran
- Gottlieb Stephen
- Goudev Assen
- Goudev Assen R.
- Gray Wayne
- Grazette Luanda
- Greco Oswaldo
- Grewal Gurinder
- Groote Pascal De
- Gueffet Jean‐Pierre
- Guerrero Rodolfo Andres Ahuad
- Gupta Dinesh
- Gupta Milan
- Guray Umit
- Haddad Tariq
- Haehling Stephan
- Hajko Erik
- Hal John
- Halpern Stephen
- Hametz Craig
- Hamilton Andrew
- Han Qinghua
- Han Yajun
- Handel Franklin
- Hara Hisao
- Harris John
- Hart Hamish
- Hart Terence
- Hartleib Michael
- Hasni Syed
- Hata Yoshiki
- Hattler Brack
- Hearne Steven
- Hedgepeth Chester
- Heilman Karl
- Heitner John
- Henderson David
- Herczeg Bela
- Hermans Walter
- Herzog William
- Hidaka Takayuki
- Hidalgo Mario Yanez
- Higashino Yorihiko
- Hiroi Shitoshi
- Hominal Miguel Angel
- Horacek Thomas
- Houra Marek
- Houston Brian
- Howlett Jonathan G.
- Huang He
- Huber Kurt
- Huelsmann Martin
- Hullin Roger
- Hunter Vernon
- Huynh Thao
- Ibañez Julio
- Ibrahim Hassan
- Indolfi Ciro
- Inomata Takayuki
- Iseki Harukazu
- Ishikawa Masahiro
- Isnard Richard
- Isshiki Takaaki
- Itchhaporia Dipti
- Ito Hiroshi
- Jackson Bruce
- Jacob Binu
- Jadbabaie Farid
- Jaeger Cristiano Pederneiras
- Jaffrani Naseem
- Jalaf Margarita Gertrudis Vejar
- Janik Matthew
- Jankowski Piotr
- Janmohamed Munir
- Jarasuniene Dalia
- Jattin Fernando Manzur
- Javier Julian
- Jeppesen Jorgen
- Jerabek Ondrej
- Jimenez Juan Francisco Delgado
- Jofre Christian Paolo Pincetti
- Jondeau Guillaume
- Jones Alonzo
- Joseph Susan
- Juanatey Jose Ramon Gonzalez
- Judkins Christopher
- Kadel Christoph
- Kadokami Toshiaki
- Kafara Mariusz
- Kai Hisashi
- Kaiser‐Nielsen Peter
- Kajinami Kouji
- Kalarus Zbigniew
- Kalecinska‐Krystkiewicz Ewa
- Kalra Paul
- Kaluski Edo
- Kanda Junji
- Kania Grzegorz
- Kao John
- Karavidas Apostolos
- Karim Amin
- Karlstrom Patric
- Karpenko Oleksandr
- Karvounis Haralambos
- Kasai Toshio
- Kassiotis Christos
- Katz Richard
- Kawakami Hideo
- Kawamitsu Katsunori
- Kawasaki Tomohiro
- Kazemi Navid
- Kazinczy Rita
- Kearney Leighton
- Keeling Philip
- Kellnerova Ivana
- Khalife Wissam
- Kida Keisuke
- Killat Holger
- Kindel Carlos Conejeros
- King Anthony
- Kirma Cevat
- Kitaoka Hiroaki
- Klimsa Zdenek
- Klug Eric
- Kobalava Zhanna
- Kochiadakis George
- Koga Tokushi
- Koike Akihiro
- Koizumi Tomomi
- Koldas Zehra Lale
- Koleckar Pavel
- Komiyama Nobuyuki
- Kondo Nicholas
- Konieczynska Malgorzata
- Kono Alan
- Koo Charles
- Kopaczewski Jerzy
- Korczyk Dariusz
- Koren Michael
- Korzh Oleksii
- Kosmacheva Elena
- Kostenko Viktor
- Kotelnikov Mikhail
- Kowalski Robert
- Kracz Igor
- Krantz Mori
- Krishnamoorthy Arun
- Krupicka Jiri
- Kryza Radim
- Kubota Toru
- Kulibaba Elena
- Kulynych Oleksii
- Kurtz Christopher E.
- Kwan Michael
- Lader Ellis
- Lakatos Ferenc
- Lakshminarayanan Batlagundu
- Lancellotti Patrizio
- Lanfear David E.
- Lang Chim
- Lang Christopher
- Laperche Thierry
- Laszlo Zoltan
- Leaes Paulo Ernesto
- Lefebvre Jean‐Marie
- Legg Jason C.
- Leiro Maria Generosa Crespo
- Lelonek Malgorzata
- Lenartowska Lucyna
- Lenner Egon
- Leon Jose Luis Arenas
- Leonardi Sergio
- Lepor Norman
- LeWinter Martin
- Lewis Neil
- Li Dongye
- Li Jianjun
- Li Tianfa
- Li Weimin
- Li Yinjun
- Li Zhangquan
- Li Zhaoping
- Lighezan Daniel
- Lindholm Carl‐Johan
- Linssen Gerardus
- Liu Feng
- Llamas Edmundo Alfredo Bayram
- Llerena Sara
- Lohr Nicole
- Londono Juan
- Lopez Gabriel Arturo Ramos
- Lopez Luis Horacio Atehortua
- Lopez Rodrigo Botero
- Lovell Charles
- Ludman Andrew
- Luengas Carlos Alberto
- Lukacova Jana
- Lukyanov Yury
- Lund Marianne
- Lund Mayanna
- Lupkovics Geza
- Lupovitch Steven
- Luquez Hugo
- Lymar Yurii
- Lynch Mary
- Ma Shumei
- Macarie Cezar‐Eugen
- Macdonald Peter
- Macdonald Peter
- Machado Gustavo Francisco Mendez
- Machova Vilma
- Macias Leonardo
- Mackinnon Ignacio
- Maejima Yasuhiro
- Magro Michael
- Mahemuti Ailiman
- Mahmood Shahid
- Maia Lilia Nigro
- Majercak Ivan
- Majul Claudio Rodolfo
- Malhotra Sanjay
- Malhotra Vinay
- Malik Adnan
- Malik Fady I.
- Mamdani Shafiq
- Mancini Donna
- Manenti Euler Roberto Fernandes
- Manita Mamoru
- Manolis Athanasios
- Mantas Ioannis
- Mareev Vyacheslav
- Mareev Vyacheslav
- Margoczy Roman
- Margonato Alberto
- Mark Laszlo
- Marquez Lilia Luz Lobo
- Martindale Jeffrey
- Martinez Diego Felipe
- Martinez Laura Jordan
- Martinez Luis
- Martinez‐Arraras Joaquin
- Martinez‐Castrillon Melvin
- Marzouka George
- Masuda Seigo
- Matsumoto Takashi
- Mayer Nolan
- Mayoral Alejandro Recio
- McGrew Frank
- McKelvie Robert
- McKenzie Scott
- McLean Dalton
- McMurray John J.V.
- Menck Niels
- Mendoza Jose Luis Accini
- Mendoza Maria Alexandra Arias
- Merkely Bela
- Metra Marco
- Metra Marco
- Meyer Philippe
- Mi Yafei
- Michishita Ichiro
- Miekus Pawel
- Mielniczuk Lisa
- Mignone John
- Militaru Constantin
- Mincheva Valentina
- Mishchenko Larysa
- Mitrokhin Vladislav
- Mitrovic Veselin
- Mitsuo Kazuhisa
- Mittag Marcus
- Mitu Florin
- Miura Shinichiro
- Miyamoto Michael
- Miyamoto Nobuhide
- Miyazaki Tetsuro
- Moccetti Tiziano
- Mody Freny
- Moe Gordon
- Moertl Deddo
- Mohacsi Attila
- Mohapatra Robert
- Molina Beatriz Diaz
- Momiyama Yukihiko
- Momomura Shin‐ichi
- Monhart Zdenek
- Montana Oscar Romano
- Monteiro Pedro
- Moodley Rajendran
- Mori Masuki
- Morita Yukiko
- Morrow John Andrew
- Mortara Andrea
- Mostovoy Yuriy
- Motovska Zuzana
- Motylev Igor
- Mouhaffel Asad
- Muderrisoglu Ibrahim Haldun
- Mueller Christian
- Murray David
- Muthumala Amal
- Myasnikov Roman
- Nadar Venkatesh
- Nagy Laszlo
- Nair Nandini
- Naka Katerina
- Nakamura Akihiro
- Nakamura Kentaro
- Nalbantgil Sanem
- Nechvatal Libor
- Nelson William
- Nessler Jadwiga
- Nguyen Viviane
- Nicolosi Liliana
- Nielsen Tonny
- Niu Wentang
- Node Koichi
- Noll Georg
- Nosov Vladimir
- Novaretto Leonardo
- Numaguchi Kotaro
- Nyolczas Noemi
- Nyvad Ole
- O'Brien Terrence
- O'Meara Eileen
- O'Meara Eileen
- Ogawa Tomohiro
- Oishi Shogo
- Okishige Kaoru
- Okumura Takahiro
- Okumura Yasuo
- Okuyan Ertugrul
- Oliveira Soares Manue Martinez‐Selles D
- Oliveira Luis
- Olsen Stephanie
- Onoue Kenji
- Onrat Ersel
- Ooi Henry
- Orgera Marisa
- Ortiz Aurelio
- Osipova Irina
- Osorio Wilder Castaño
- Ovize Michel
- Padron Antonio Lara
- Paiva Maria Sanali
- Palomas Juan Luis Bonilla
- Pandey A Shekhar
- Paolino Bruno
- Papp Andras
- Papp Aniko
- Pareja Monica Lopez
- Parissis John
- Parkhomenko Alexander
- Parkhomenko Oleksandr
- Parody Maria Leonor
- Paszczuk Anna
- Patel Devesh
- Patsilinakos Sotirios
- Pauwaa Sunil
- Pawlowicz Lidia
- Paya Vicente Eduardo Climent
- Peart Brenda
- Peiro Maria Teresa Blasco
- Pelaez Sebastian Velez
- Perez Sonia Mirabet
- Perna Eduardo
- Perna Gianpiero
- Pesant Yves
- Peterka Karel
- Peterson Magnus
- Petrov Ivo
- Pfister Roman
- Pham Michael
- Phaneuf Denis‐Carl
- Pianko Leonard
- Piatek Marek
- Picard François
- Pickett Christopher
- Piegas Leopoldo Soares
- Pijanowski Zbigniew
- Pillutla Priya
- Pimenov Leonid
- Pini Daniela
- Piovaccari Giancarlo
- Pisani Barbara
- Podoleanu Cristian Gheorghe
- Podpera Ivo
- Poelzl Gerhard
- Polasek Rostislav
- Ponikowski Piotr
- Popescu Mircea Ioachim
- Portnay Edward
- Postadzhiyan Arman
- Potthoff Sergio
- Poy Carlos
- Pozdisek Zbynek
- Prado Aldo
- Prado Jose Maria Arizon
- Price Dallas
- Prokhorov Oleksandr
- Proulx Guy
- Qu Yanling
- Radin Michael
- Radojevic Joseph
- Rafalskiy Vladimir
- Rahko Peter
- Rajagopalan Navin
- Rama Bhola
- Ramanathan Kodangudi
- Ramires Felix
- Ramires Felix J. A.
- Ramos Mark
- Ranadive Nandkishore
- Randall William
- Rao Sunder
- Rasmussen Mariela
- Rasputina Lesya
- Rassaf Tienush
- Rassi Salvador
- Rawitscher David
- Reis Gilmar
- Remmen Johannes
- Rennyson Stephen
- Repin Alexey
- Ricci Jean Etienne
- Rider James
- Rishko Mykola
- Rivero Mariel
- Robinson Shawn
- Rodriguez Alicia Contreras
- Rojas Pastor Olaya
- Rosamel Yann
- Rossi Paulo Roberto Ferreira
- Rossini Roberta
- Roth Sherryn
- Roubille Francois
- Rowan Christopher
- Roy Debashis
- Rudenko Leonid
- Rudyk Iurii
- Ruiz Alberto Esteban Bazzoni
- Rupka Dennis
- Ryabov Vyacheslav
- Ryding Alisdair
- Rynkiewicz Andrzej
- Römer Tjeerd
- Sabatier Rémi
- Sahin Tayfun
- Sakagami Satoru
- Sakai Tetsuo
- Sakamoto Tomohiro
- Sakata Yasushi
- Salamon Csaba
- Salazar Dora Ines Molina
- Salazar Melchor Alpizar
- Salomone Oscar Alejandro
- Salukhov Vladimir
- Salvat Muriel
- Sampognaro Gregory
- Sandri Marcus
- Santos Luis
- Saraiva Jose Francisco
- Sarmento Pedro Morais
- Sassone Sonia
- Sato Yukihito
- Sauer Andrew
- Savard Daniel
- Sawyer Douglas
- Saxena Sanjeev
- Schaap Jeroen
- Schee Alexandr
- Schiavi Lilia
- Schmalfuss Carsten
- Schnitzler Robert
- Schultz David
- Sciborski Ryszard
- Scott Russell
- Segarra Jorge Leonardo Cobos
- Semenova Irina
- Senaratne Manohara
- Senni Michele
- Sepulveda Alex Mauricio Villablanca
- Serikawa Takeshi
- Serpytis Pranas
- Serpytis Pranas
- Seto Arnold
- Shah Amit
- Shah Anil
- Shah Keyur
- Shah Nishant
- Shandling Adrian
- Sharma Mukesh
- Sharpsten Lucie
- Shayani Steven
- Sherenkov Alexander
- Shilkina Nataliya
- Shimizu Wataru
- Shimomura Mitsuhiro
- Shin Jooyoung
- Shutemova Elena
- Shvarts Yury
- Sichrovsky Tina
- Sidor Mateusz
- Silva Neto Luis Beck
- Silva Rodrigo
- Silveira Fabio
- Simoes Marcus Vinicius
- Simon Marc
- Sinagra Gianfranco
- Sindone Andrew
- Singh Deovrat
- Singh Pradeep
- Siostrzonek Peter
- Sitnikova Maria
- Skaria Binoy
- Skonieczny Grzegorz
- Skopicki Hal
- Skrobakova Janka
- Slapikas Rimvydas
- Sliwa Karen
- Sluis Aize
- Smart Frank
- Smik Rudolf
- Smilde Tom
- Sobkowicz Bozena
- Sochor Karel
- Sokos George
- Solomon Scott D.
- Solovev Oleg
- Souza Weimar Kunz Barroso
- Spacek Rudolf
- Spinar Jindrich
- Spinar Jindrich
- Spinarova Lenka
- Spiridon Marilena Renata
- Spyra Janusz
- Stahl Llyod
- Stamate Sorin
- Stanciulescu Gabriela
- Stanislavchuk Mykola
- Stankiewicz Anna
- Starling Randall
- Stepek David
- Stets Roman
- Stevlik Jan
- Stewart Robert
- Stoddard Marcus
- Straburzynska‐Migaj Ewa
- Strader J Russell
- Styliadis Ioannis
- Störk Stefan
- Sugino Hiroshi
- Sulemanjee Nasir
- Sun Yuemin
- Sussex Bruce
- Suter Thomas
- Suter Thomas M.
- Suzuki Masahiro
- Sverdlov Aaron
- Sweitzer Nancy
- Szabo Barna
- Szakal Imre
- Szasz Gyula
- Szczasny Marcin
- Szto Gregory
- Taggeselle Jens
- Tahirkheli Naeem
- Takagi Atsutoshi
- Takahashi Natsuki
- Takaishi Hiroshi
- Takama Noriaki
- Takata Theodore
- Takeishi Yasuchika
- Takenaka Takashi
- Tallet Julio
- Tanabe Jun
- Tanaka Takahiro
- Tang Huifang
- Tarasov Nikolay
- Tartiere Jean‐Michel
- Tatebe Shunsuke
- Taylor Justin
- Teerlink John R.
- Terasaki Toshiro
- Terasawa Akihiro
- Tereschenko Sergey
- Timofeev Alexander
- Tisheva‐ Gospodinova Snezhanka
- Tocchetti Carlo Gabriele
- Todorov Georgi
- Tognon Alexandre
- Tomcsanyi Janos
- Tomcsanyi Janos
- Toth Kalman
- Treasure Charles
- Trebacz Jaroslaw
- Trevelyan Jasper
- Triana Miguel Urina
- Trichon Benjamin
- Trochu Jean Noel
- Tsabedze Nqoba
- Tsao Lana
- Tseluyko Vira
- Tsioufis Konstantinos
- Tsujimoto Mitsuru
- Tuncer Mustafa
- Turgut Okan Onur
- Tyl Petr
- Tzekova Maria
- Tziakas Dimitrios
- Ueda Yasunori
- Ueno Hideki
- Uhliar Rudolf
- Ujino Keiji
- Uretsky Barry
- Usui Makoto
- Utsu Noriaki
- Vaccari Christopher
- Vakaliuk Igor
- Van Eck Jacob
- Van Kesteren Henricus
- Van Zyl Louis
- Vandekerckhove Hans
- Vandekerckhove Hans
- Vanhecke Thomas
- Varin Claire
- Vasallo Javier
- Vasilev Ivaylo
- Vasilyeva Larysa
- Vaz Garth
- Vazquez Eduardo Salcido
- Vega Mario
- Velikov Chavdar
- Venegas Manuel Eduardo Rodriguez
- Videbaek Lars
- Vidotti Maria Helena
- Vijay Nampalli
- Vilamajo Oscar Alberto Gomez
- Vilchez Francisco Gonzalez
- Villani Giovanni Quinto
- Villoch Mario
- Villota Julio Eduardo Nuñez
- Vinanska Daniela
- Vincenzi Antonella
- Vinereanu Dragos
- Vinereanu Dragos
- Vishnevsky Alexander
- Voevoda Mikhail
- Vogel Daniel
- Voicu Olga‐Cristina
- Volterrani Maurizio
- Voors Adriaan
- Voors Adriaan A.
- Voronkov Leonid
- Vraa Soren
- Wada Atsuyuki
- Wahid Faisal
- Wal Ruud
- Wang Yi
- Wang Zhifang
- Watanabe Naoki
- Wei Yu
- Weir Robin
- Westenfeld Ralf
- Wheeler Matthew
- Whellan David
- Wiggers Henrik
- Wilkett Matt
- Willems Frank
- Williams Celeste
- Wlodarczyk Aleksander
- Wodlin Peter
- Wong Kenneth
- Wozakowska‐Kaplon Beata
- Wu Weiheng
- Yagensky Andriy
- Yamamoto Mitsutaka
- Yan Jing
- Yang Ping
- Yang Xuming
- Yang Zhenyu
- Yeoman Gary
- Yigit Zerrin
- Yilmaz Mehmet B.
- Yoshida Takeshi
- Yoshikawa Masaki
- Yousuf Kabir
- Yuan Zuyi
- Yuge Masaru
- Zabowka Maciej
- Zaca Valerio
- Zaidman Cesar
- Zanetti Fernando Tomas Lanas
- Zannad Faiez
- Zapata Gerardo
- Zdrenghea Dumitru
- Zeman Kamil
- Zeymer Uwe
- Zhang Jinguo
- Zhang Lily
- Zhang Shouyan
- Zhang Xuelian
- Zhang Yuhui
- Zhang Yuqing
- Zheng Yang
- Zheng Zhe
- Zhou Changyong
- Zieroth Shelley
- Zilahi Zsolt
- Zimmet Hendrik
- Zolty Ronald
- Zrazhevskiy Konstantin
- Zwaan Coenraad
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594).
Conclusions:
GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
Youth Employment Study:Findings from the first survey
- Author
- Publication venue
- University of Melbourne
- Publication date
- 01/01/2021
- Field of study
EUREKA - Entscheidungs-Unterstützung: Rollengerecht, Effizient, Kooperativ, Allgegenwärtig
- Author
- Publication venue
- Publication date
- 09/02/2005
- Field of study
Mass-spectrometry-based lipidomics
- Author
- Abdullah
- Andreoli
- Antonny
- Armbrecht
- Ayala
- Baba
- Bamba
- Berdyshev
- Besnard
- Birjandi
- Bligh
- Bollinger
- Brandsma
- Brown
- Burdin
- Cai
- Capra
- Carlo
- Casanovas
- Castro-Perez
- Choi
- Christie
- Dai
- Deng
- Dennis
- Didangelos
- Dimov
- Ecker
- Fahy
- Fahy
- Ferreiro-Vera
- Fillmore
- Folch
- Fuchs
- Fung
- Gao
- Gong
- Greene
- Griesinger
- Grillitsch
- Han
- Han
- Haraszti
- Harrison
- Hasin
- Haynes
- Hsu
- Hsu
- Hsu
- Hu
- Huang
- Ibanez
- Jensen
- Jensen
- Jin
- Jol
- Jones
- Kainu
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- Kainu
- Kanu
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- Mendiara
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- Mitchell
- Moe
- Monroe
- Muir
- Nawaz
- Oh
- Otvos
- Paglia
- Pan
- Passarelli
- Passos-Castilho
- Pechlaner
- Pizarro
- Poschner
- Postle
- Postle
- Qu
- Qu
- Rangiah
- Raposo
- Rioux
- Roman
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- Sabido
- Salieb-Beugelaar
- Sethi
- Sewell
- Shrestha
- Soderholm
- Son
- Spitzer
- Stahlman
- Starai
- Storms
- Sun
- Tamae
- Tan
- Teo
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- Thomas
- Thomas
- Thomas
- Thomas
- Tie
- Tokimitsu
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- Tsuyama
- Vatarescu
- Virot
- Vrkoslav
- Vrkoslav
- Wang
- Wang
- Wang
- Wang
- Wang
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- Weibel
- Wenk
- Williams
- Xu
- Xu
- Yamada
- Yamamoto
- Yamamura
- Yan
- Yang
- Yang
- Yeo
- Zanfini
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- Zhang
- Zhang
- Zhang
- Zhao
- Zheng
- Zhu
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Collective Efficacy of a Regional Network: Extending the Social Embeddedness Perspective of Entrepreneurship
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- Albert Shapero
- Alistair R Anderson
- Alistair R Anderson
- Alistair R Anderson
- Alistair R Anderson
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- Alistair R Anderson
- Amartya K Sen
- Ana Peredo
- Ana Peredo
- Andrea Larson
- Anthony R Zito
- Arent Greve
- Arnold C Cooper
- Babara J Bird
- Barbara M Byrne
- Bat Batjargal
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- Bill Mcevily
- Catherine Cramton
- Claudine Kearney
- Craig J Thompson
- Dale H Schunk
- David A Harper
- David G Blanchflower
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- Dean A Katz
- Deborah H Francis
- Dennis R Young
- Dilek Cetin
- Dimo P Dimov
- Direcci�n Y Econom�a De La Empresa
- Don Lavoie
- Don Y Lee
- Douglas W Lyon
- Edward Goodman
- Edward P Lazear
- Emin Ada?
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- Firm Entrepreneurship
- Francis Fukuyama
- Francis Fukuyama
- Frank Pyke
- Fransesco Castellaneta
- Giacomo Beccattini
- Gopalkrishnan R Iyer
- Gopalkrishnan R Iyer
- Gopalkrishnan R Iyer
- Gopalkrishnan R Iyer
- Hanna Papanek
- Helena Yli-Renko
- Ian R Gordon
- Iqbal M Khan
- Ivan Light
- Izrael M Kirzner
- J Cunningham
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- Jiangyong Lu
- Joern H Block
- John S Butler
- Judith B Kamm
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- Kathleen M Eisenhardt
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- Lianxi Zhou
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- M Wasko
- Mancur Oslon
- Maria Minniti
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- Masako Ueda
- Matthias Jerusalem
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- Abbyad P.
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- Publication venue
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- Field of study
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- Andrássy Péter
- Angerås Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
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- Assanelli Emilio
- Atieh Mahmoud
- Auer Johann
- Avino David
- Babapulle Mohan
- Babilonia Noe
- Babilonia Noe A
- Bae Jang-Whan
- Baglikov Andrey
- Bailey Allan
- Bailey Gordon
- Bain Stephen
- Bakai Judit
- Bakhtari Ladan
- Ballyuzek Marina
- Bander Jeffrey
- Bandh Stellan
- Banerjee Subhash
- Banerjee Supratim
- Banerjee Suvro
- Barabashkina Anna
- Baracioli Luciano
- Barbarash Olga
- Barbas Benny
- Barettella Mark
- Bashkin Amir
- Basiak Marcin
- Baszak Jacek
- Bata Iqbal
- Bauer Michael
- Bayat Junaid
- Bazari Rasha
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- Bellotti Sandro
- Belohlavek Jan
- Benczur Bela
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- Berger Rudolf
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- Bertrand Olivier
- Bertsch John
- Besada Diego
- Bessoudo Ricardo
- Beth Mary
- Bhargava Anuj
- Bhatt Deepak L
- Bhatt Deepak L
- Bhavsar Janak
- Bijata-Bronisz Renata
- Bittar George
- Bitters J'Cinda
- Black Robert
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- Blick David
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- Bongo Angelo S
- Bordonava Anselmo
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- Botero Rodrigo
- Botero Rodrigo
- Bott Jochen
- Bouza Manuel
- Boyrazian Hagop
- Brabham David
- Braganza Denise
- Brath Helmut
- Brockmyre Andrew
- Broker Robert
- Brown Christopher
- Buchbinder Maurice
- Bueno Héctor
- Bugan Viliam
- Bula Larysa
- Burgess Lesley
- Busak Ladislav
- Busch Robert
- Busz-Papiez Benita
- Butman Samuel
- Buysschaert Ian
- Byanov Kolyo
- Cabrera Walter
- Calabrò Paolo
- Cantu Elias G
- Cantú Arnulfo G
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- Chacon Carolina
- Chae In-Ho
- Chae Jei-Keon
- Chag Milan
- Chai Yingru
- Chamnarnphol Noppadol
- Chan Michael
- Chan Shih-Hung
- Chang Kiyuk
- Chang Kuan-Cheng
- Chatrathi Sridhar
- Chavez Carlos
- Chehayeb Raja
- Cheirif Jorge
- Chen Jersey
- Chen Jersey
- Chen Zhih-Cherng
- Chernyavsky Alexander
- Cheung Deanna
- Cheung Stephen
- Chhabra Anil
- Chiang Chern
- Chiang Chern-En
- Choi Si-Wan
- Choi Young J
- Chompalova Boryana
- Chorin Ehud
- Chouinard Guy
- Cinteza Mircea
- Clavijo Leonardo
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- Cobos Jorge
- Coching Raul M
- Coetzee Kathleen
- Colfer Harry
- Colquhoun David
- Coman Ioan
- Conejeros Carlos
- Constance Christian
- Corbalan Ramon
- Corbalán Ramón
- Corder Clinton
- Cordova Fernando
- Cornel Jan H
- Cornel Jan H
- Cortada Jorge B
- Cottin Yves
- Coussement Patrick
- Cox John
- Creteanu Mihai
- Crijns Hendrikus
- Curiac Dan
- Cygler Jerzy
- Cymerman Krzysztof
- Czigány Anna
- Czochra Wojciech
- Czyzycki Mariusz
- D'Agostino Ronald
- D'Urso Michael
- Dada Fredy T
- Dalby Anthony
- Dalby Anthony J
- Danchin Nicolas
- Danchin Nicolas
- Dantzig Jan-Melle
- Darius Harald
- Dart Anthony
- Das Asit
- Dawood Saleem
- de Cosmo Salvatore
- de la Torre Hernández José M
- de Labriolle Axel
- de los Ríos Ibarra Manuel
- de Luca Leonardo
- de Maeseneire Stefan
- de Melker Edwin
- de Nooijer Cornelis
- de Souza Weimar
- Debs-Perez Giselle
- Decoulx Eric
- Dedek Vratislav
- Deering Joseph
- DeGregorio Michele
- Dehghani Payam
- del Blanco Bruno G
- Delforge Marc
- Demchenko Elena
- Desai Pratik
- Deyoung Michael
- Di Pasquale Giuseppe
- Diaz Rafael
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- Dickert Jim
- Didenko Yury
- Dimov Bojidar
- Dincheva Adriana
- Dion Danielle
- Distiller Lawrence
- Dixen Ulrik
- Do Huan
- Dobreanu Viorica
- Doi Tomofumi
- Dolzhenko Maryna
- Domínguez Antonio R
- Dong Xiaolin
- Dor Isaac
- Dorsch Micha
- dos Santos Fabio R
- Dotsenko Sergiy
- Doyle Timothy
- Drelich Grzegorz
- Drexel Heinz
- Drozd Marcin
- Dubreuil Olivier
- Dumas Richard
- Duronto Ernesto
- Dutra Oscar
- Dy Johnny
- Dzhaiani Nino
- Díaz Fernández José F
- Díaz Francisco F
- Eaves William
- Ebenbichler Christoph
- Eder Frank
- Edin Anton
- Egstrup Kenneth
- Eki Yutaka
- El Salah
- El-Amin Omer
- Elamin Omer
- Elbaz Meyer
- Elbl Lubomir
- Eliaschewitz Freddy
- Emerson Ronald
- Ereño Ainhoa R
- Erlinge David
- Ermoshkina Lyudmila
- Eshaghian Shervin
- Estrada José N
- Ezhov Andrey
- Faes Dirk
- Fang Chih
- Fares Issa
- Farsky Stefan
- Fazekas Frantisek
- Feldman Robert
- Fernández Portales Francisco J
- Ferrario Emile
- Ferrario Maurizio
- Ferrolino Arthur
- Figueiredo Estevao
- Figueroa Christian
- Fil Wojciech
- Fillat Angel C
- Fischer Sabine
- Fischer Stuart
- Fließer-Görzer Evelyn
- Fontaine Caroline
- Forgosh Leslie
- Forte Adriana
- Fortes Jose A
- Foster Malcolm
- Foster Michael
- Fourie Nyda
- Fox Kim
- Fox Kim
- Franchetti Marcos
- Frandsen Brad
- Fraser Neil
- Frechette Andre
- French William
- Fresco Claudio
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- Nechaeva Galina
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- Raisinghani Ajit
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- Ramamurthee Kannaiyan
- Ramanathan Krishnan
- Ramos López Gabriel A
- Randeva Harpal S.
- Range Gregoire
- Ranjith Naresh
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- Reddy M
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- Urbano Rafael H
- Urbinati Stefano
- Uretsky Barry
- Utsu Noriaki
- Uzunow Anna
- Vaca Carlos
- Vakaliuk Igor
- Valle Timo
- Vallejo Gregorio S
- van de Wal Ruud
- van den Heuvel Christian
- van der Zwaan Coen
- van Eck Martijn
- van Kesteren Henricus
- van Zyl Louis
- Varbella Ferdinando
- Varleta Paola
- Vasconcellos Eduardo
- Vasilyeva Larisa
- Vatova Ralitsa
- Vega Damaris
- Velichko Nataliia
- Vera Tomás R
- Vervoort Geert
- Verwerft Jan
- Viktorova Inna
- Vilamajo Oscar G
- Villablanca Alex
- Vinanska Daniela
- Vinereanu Dragos
- Vinereanu Dragos
- Vishneva Elena
- Vishnevsky Alexander
- Viswanathan Girish
- Vizel Saul
- Viñas Jaime A
- Vlastaris Anthony
- von Engelhardt Charlotte
- von Münchhausen Candy
- Vora Kishor
- Voyce Steven
- Vrolix Mathias
- Vykoukalova Tatiana
- Wang Hao
- Wang Ji-Hung
- Wang Yi-Chih
- Weiderman Ann-Charlotte
- Weigmann Ingo
- Weirick Troy
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- Welch Michelle
- Welter Ryan
- Werner Henri
- Westendorp Iris
- Whelan Alan
- Widimský Petr
- Wierucki Lukasz
- Wilderman Igor
- Wilke Andreas
- Willems Frank
- Willis John
- Wilson Vance
- Wilson William
- Wiseman Alan
- Witek Robert
- Wojcik Ronald
- Wojnowski Lukasz
- Wolzt Michael
- Wong Brian
- Wong Michelle
- Wongvipaporn Chaiyasith
- Woolf Kevin
- Worthley Matthew
- Wozakowska-Kaplon Beata
- Wu Chih-Cheng
- Wu Yen-Wen
- Wujkowski Marek
- Yagensky Andriy
- Yakushin Sergey
- Yalcin Ahmet
- Yamamoto Fumi
- Yaneva Zdravka
- Yeh Hung-I
- Ying Man
- Yokoya Koichi
- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano Gómez José L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- Zólyomi Szilárd
- Édes István
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk
Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events The ODYSSEY OUTCOMES Trial
- Author
- Abbas Jalal
- Abbate Antonio
- Abdullakutty Jabir
- Abdullkutty Jabir
- Abhyanakar Atul D.
- Aboyans Victor
- Abrantes Jose Antonio M.
- Abu-Fadel Mazen
- Acevedo Monica
- Adamkova Vera
- Adamo Antony
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Aggarwal Rahul
- Aggarwal Rajesh K.
- Agnetti Veronique
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A.
- Aidar Ayoub Jose Carlos
- Airaksinen Juhani K.
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea Y. Y.
- Alan David
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M.
- Alexopoulos Dimitrios
- Alings Marco
- Alonso Martin Joaquin J.
- Alonso Orcajo Norberto
- Alsweiler Caroline
- Alvarisqueta Andres F.
- Alves De Lima Alberto E.
- Amarasekera Stanley
- Amarasena Naomali
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Anchante Hernandez Henry A.
- Andersen Dorthe
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Ando Kenji
- Angel Hominal Miguel
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Aroney Constantine
- Arroyo Julian A. Coronel
- Arstall Margaret A.
- Asanin Milika R.
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Aylward Phil
- Aylward Philip E.
- Azizad Masoud M.
- Badreddine Emmy
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Balaguer Recena Javier
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Bang Lia E.
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L.
- Barbato Emanuele
- Barna Olga M.
- Barone-Rochette Gilles
- Barr Craig
- Barraud Pauline
- Barrucco Robert
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- Bashir Riyaz
- Bastos Jose Mesquita
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Bejuit Raphael
- Bekkouche Mhamed
- Belhassane Abdelkader
- Beltran Pascale
- Benbernou Fadela
- Bencic Martina Lovric
- Benecke Juan L. Arango
- Benedicto Amparo
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- Berman Brett
- Bernan Alisa
- Berthou Christelle
- Berti Sergio
- Bezault Madeleine
- Bhagwat Ajit
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- Bhansali Prasant
- Bhatt Deepak L.
- Binder Ronald
- Birchem Jessica
- Bittner Vera A.
- Blicharski Tomasz
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- Botelho Ana
- Botelho Roberto V.
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- Bottcher Morten
- Bouancheau Cecile
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- Bourgeois Ronald
- Brabham David
- Braganza Denise
- Braun-Dullaeus Ruediger
- Bravo Mannucci Jorge E.
- Breedveld Robert W.
- Bregeault Marie-France
- Brennan J. Matthew
- Brigui Imane
- Brocklehurst Maddy
- Brodison Adrian
- Bronzwaer Patrick N. A.
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- Bruguera Cortada Jordi
- Budaj Andrzej
- Bugan Viliam
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- Chengyue Zhu
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- Chopra Vijay K.
- Chotnoparatpat Paiboon
- Christenson Stuart
- Chu Alan
- Chua Terrance
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- Citron Bernard
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- Claeys Marc J.
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- Coca Payeras Antonio
- Coching Raul Martin
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- Corbett Clive
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- Dong Shaohong
- Dong Yugang
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- Mendoza Jose L. Accini
- Mentz Robert J.
- Merkely Bela
- Metwally Lamia
- Michalaros Yorghos L.
- Michaud Nicolas
- Michishita Ichiro
- Micko Karol
- Midzic Zlatko
- Miklaszewicz Beata
- Mileta Dean
- Milicic Davor
- Militaru Constantin
- Mincheva Valentina M.
- Minescu Bogdan
- Mintale Iveta
- Mirek-Bryniarska Ewa
- Misonis Nerijus
- Moccetti Tiziano
- Mody Freny
- Mogrovejo Ramos Walter
- Mohamed Wan Mohd Izani Wan
- Mohart Ann Elizabeth
- Molchanova Olga
- Mollov Mihail N.
- Monier Myriam
- Montalescot Gilles
- Montana Oscar R.
- Montecinos Humberto
- Monteiro Minguel R.
- Monteiro Pedro
- Moodley Rajendran
- Morais Joao
- Morales Dante D.
- Morales Ulises
- Moran Joseph
- Moreira Humberto Graner
- Morel Olivier
- Moriarty Andrew
- Moriarty Patrick M.
- Morino Yoshihiro
- Moris De La Tassa Cesar
- Morisset Anne
- Morrello Christine
- Moryusef Angele
- Mosseri Morris
- Mostovoy Yuriy
- Motovska Zuzana
- Moura Jorge Jose C.
- Mourgues Maxime
- Mourtzinis Georgios
- Mrabti Asmaa
- Mthombeni Bicky
- Mudawi Telal
- Muenzel Thomas
- Mulkay Angel
- Muller Christian
- Muller Gabor
- Munk Peter S.
- Munusamy Vengatesh
- Murin Jan
- Murphy Judith
- Murphy Sherrill
- Muslibegovic Adis
- Musumeci Giuseppe
- Muthusamy Rangasamy
- Mutlu Bulent
- Mynhardt Joseph H.
- Myshanych Halyna
- Nacoud Ackar Alfredo
- Nager Paul
- Nagy Lajos
- Nahhas Ahed
- Nahuelpan Leonardo
- Nani Sebastian
- Naplava Robert
- Natour Mohammed
- Negron Miguel Sandra A.
- Nelson William
- Neuenschwander Fernando
- Neustel Mark
- Nicol Peter
- Nicolau Jose C.
- Nielsen Peter Kaiser
- Nielsen Tonny
- Nieminen Markku S.
- Nigro Frank
- Nijmeijer Remco
- Nikolaev Konstantin
- Nikolov Fedya P.
- Nikolsky Eugenia
- Nishibe Akira
- Nociar Jan
- Nogareda Gustavo
- Norkiene Sigute
- Normand Mickael
- Novaretto Leonardo P.
- Novo Salvatore
- Novoa Federico
- Novotny Vojtech
- Nowins Rosemary
- Nunez Fragoso Juan Carlos
- Nygard Ottar
- O'Donnell Philip J.
- Okan Betim
- Olexa Peter
- Olivares Claudia
- Oliveira Janaina
- Oliver Richard
- Olsson Anders G.
- Omran Heyder
- Ong Hean Yee
- Ong Tiong Kiam
- Ono Yujiro
- Oomen Antonius
- Oomman Abraham
- Oqueli Flores Romulo E.
- Orlikova Olga
- Osokina Natalya
- Ostadal Petr
- Ourliac Anne
- Ovando Sergio R. Fausto
- Paganelli Franck
- Pagava Zurab
- Palimkar Priya
- Palka Juraj
- Palmer Bruce
- Palvarini Michela
- Panchal Vipul
- Pancholy Samir
- Pandey Amritanshu
- Pandurangi Ulhas
- Parada Jeffrey Castellanos
- Parepa Irinel R.
- Park Hun Sik
- Park Hyeun (Tom)
- Parkhomenko Alexander
- Parthenakis Frangkiskos
- Pascual Andrea
- Pasquini John
- Patange Aparna
- Patel Chetan B.
- Paterlini Gustavo A.
- Patil Sachin N.
- Patki Nitin
- Patocchi Cristian A.
- Patsilinakos Sotiris
- Pawlowicz Lidia
- Pearce Stephen
- Pecin Ivan
- Pella Daniel
- Pellan Valerie
- Peng Daoquan
- Penny William, Jr.
- Pepine Carl
- Pereira Edward
- Pereira Helder H.
- Pereira Sabrina Bernardez
- Perez Rios Jesus Antonio
- Perez Luis
- Peris Vicente Bodi
- Perkins Lynn
- Perlmutter Neal
- Persic Viktor
- Perthuis Aurelie
- Pesant Yves
- Petranov Stanislav L.
- Petrulioniene Zaneta
- Piatti Piermarco
- Picault Patrick
- Picone Mark
- Piepiorka Marek
- Pillay Thayabran
- Pimentel Filho Pedro
- Pincetti Cristian
- Pintaric Hrvoje
- Piovaccari Giancarlo
- Pirenne Bruno
- Piyayotai Dilok
- Plaza Perez Ignacio
- Podoleanu Cristian G. C.
- Podpera Ivo
- Poh Kian-Keong
- Pojskic Belma
- Poklukar Janez
- Pollock Stewart
- Ponce George
- Pontaga Natalija
- Pope Theodore
- Pordy Robert
- Porthan Kimmo
- Porwal Sanjay
- Posio Pirjo
- Pothineni Ramesh B.
- Potthoff Sergio
- Poulsen Steen Hvitfeldt
- Povolny Petr
- Povsic Thomas J.
- Povzun Anton
- Precoma Dalton B.
- Premchand Rajendra K.
- Prieto Juan C.
- Prieto Juan-Carlos
- Probst Vincent
- Proddutur Naveen Reddy
- Prokhorov Alexander
- Prvulovic Deiti
- Puccioni Enrico
- Puri Sanjeev
- Purow Joshua
- Putnikovic Biljana
- Puymirat Etienne
- Qu Baiming
- Quintero Kirby
- Raczak Grzegorz
- Radin Michael
- Radovanovic Slavica
- Raev Dimitar H.
- Raffel Owen
- Raffo Carlos A.
- Raghuraman Bagirath
- Rahman Aref
- Raisinghani Ajit
- Rajapaksha Ajantha
- Ramos Lopez Gabriel Arturo
- Ranadive Nandkishore
- Ranjith Naresh
- Rao Sunder
- Rasmanis Gundars
- Ratky Caroline
- Rauch-Kroehnert Ursula
- Raungaard Bent
- Ray Kausik K.
- Ray Michael
- Rech Rafael
- Reiner Zeljko
- Reis Gilmar
- Reis Helder J. L.
- Rensing Bernard J. W. M.
- Repincay Jerome
- Reshetko Olga
- Reshotko Dmytro
- Reuter Helmuth
- Reynolds Timothy
- Rha Seungwoon
- Ricca Vittorio
- Rider James
- Rieker Werner
- Rishko Mykola
- Ristic Arsen D.
- Ritt Luiz Eduardo F.
- Roberts-Thomson Philip
- Robinson Simon
- Rodes-Cabau Josep
- Rodriguez Chavez V-ctor E.
- Roe Matthew T.
- Rogelio Gregorio
- Rogers James F.
- Rogers William, Jr.
- Rokyta Richard
- Roldan Concha Yudy M.
- Romeo Stefano
- Rondel Christelle
- Ronner Eelko
- Roosen John
- Rorick Tyrus
- Rose Gregory
- Rosenberg Michael
- Rosenschein Uri
- Rosenson Robert
- Rossi Paulo R. F.
- Rossi Peter
- Rosu Doina
- Rouleau Jean-Lucien
- Rovito Carla
- Rozeman Phillip
- Rozenman Yoseph
- Rubenstein Howard
- Rudenko Anatolii
- Rudenko Leonid
- Ruiz Ricardo L. Fernandez
- Saaiman Jan A.
- Saathe Shireesh
- Saavedra Silvia S.
- Sabatino Kenneth
- Sabbah Eric
- Sader Mark
- Sakagami Satoru
- Sakalyte Gintare
- Sakamoto Tomohiro
- Salcido Vazquez Eduardo
- Salomone Rodolfo
- Salvioni Alessandro
- Saminsk Krzysztof
- Sanabria Perez Enrique S.
- Sandhu Manjinder
- Sansanayudh Nakarin
- Santharaj Wijeyasingam
- Saporito Wladmir
- Sarkar David
- Sarvan Mahomed
- Sasiela William J.
- Sassone Sonia A.
- Sastravaha Krisada
- Sathe Shireesh
- Savard Daniel
- Sawhney Jitendra
- Scemama Michel
- Schaeufele Tim
- Schellenberg Detlev
- Schiavi Lilia B.
- Schiele Francois
- Schifferdecker Branislav
- Schmalfuss Carsten
- Schmedtje John F., Jr.
- Schmidberg Jorge M.
- Schmidt Ekkehard
- Schmitt Susanne
- Schuchard Timothy
- Schwartz Gregory G.
- Schwartz Michael
- Schwartz Steven
- Sciborski Ryszard
- Scott Douglas
- Sebastian Peter J.
- Seferovic Petar
- Seixo Filipe
- Selecky Juraj
- Senaratne Manohara
- Senaratne Vajira
- Sethi Sumeet
- Shaburishvili Tamaz
- Shah Anil V.
- Shah Bimal R.
- Shah Vipul
- Shalaev Sergey
- Sharman David
- Shaw James
- Shaw Michelle
- Shechter Michael
- Shehova-Yankova Nina S.
- Sheldon William
- Sheller Jennifer
- Sherwood Matthew W.
- Shetty Sanjay
- Shi Xubo
- Shimizu Masatoshi
- Shinde Rituparna
- Shinke Toshiro
- Shogenov Zaur
- Shou Xiling
- Shoukfeh Mohammad
- Shustov Sergey
- Shvarts Yury
- Sijbrands Eric J. G.
- Sikic Jozica
- Silva Ricardo P.
- Silva Sandra I. Barrera
- Silveira Jose A.
- Silver Kevin
- Simaitis Audrius
- Sime Iveta
- Simic Dragan
- Simon Tabassome
- Simonis Gregor
- Simoons Maarten L.
- Singal Dinesh
- Singh Narendra
- Singsaas Erlend Gyllensten
- Sinha Dhurjati
- Sinnaeve Peter
- Sionis Dimitrios
- Sirisena Thilak
- Siu David C. W.
- Skonieczny Grzegorz
- Skorski Marcin
- Skoumas Ioannis
- Slapikas Rimvydas
- Smik Rudolf
- Smith Lucile
- Soggia Ana Priscila
- Soonfuang Wasant
- Soopold Ullar
- Soots Mai
- Sopena Sebastien
- Soran Handrean
- Soroka Eugene
- Sotnikova Tatiana
- Sotty Marc
- Sousa Luciano
- Souza Weimar K. S. B.
- Soward Allan
- Sparby Jon Arne
- Speirs Shawn
- Spinar Jindrich
- Sporn Daniel
- Spriggs Douglas
- Sritara Piyamitr
- Stambuk Kresimir
- Staneta Pawel
- Stanislavchuk Mykola
- Stankovic Aleksandar
- Starcevic Boris
- Starmer Gregory
- Stasek Josef
- Stasiewski Arkadiusz
- Steg Gabriel
- Steg Ph. Gabriel
- Steiner Stephan
- Stellbrink Christoph
- Stewart Ralph
- Stojic Stevo
- Stone James
- Storey Robert
- Strader James, Jr.
- Strain Janet
- Stratmann Matthias
- Strbova Jaroslava
- Strelnieks Aldis
- Striekwold Harry
- Stringfellow Kenya
- Strozzi Maja
- Stryuk Raisa
- Su Guohai
- Su Xi
- Suarez Otero Rodrigo
- Subkovas Eduardas
- Sudnik Wanda
- Sugino Hiroshi
- Suh David
- Sujjavanich Darin
- Sukonthasarn Apichard
- Suligoj Natasa Cerni
- Sulit Dennis Jose
- Sumner Andrew
- Sun Yingxian
- Sun Yuemin
- Sundelin Torbjorn
- Sundram P. Sandy
- Suryapranata Harry
- Sussex Bruce
- Svab Premysl
- Sy Rody G.
- Sy Rosa Allyn G.
- Sydow Karsten
- Szarek Michael
- Szpajer Michal
- Szwed Hanna
- Taguchi Shuichi
- Tahk Seung-Jea
- Takahashi Toshiyuki
- Takata Theodore
- Takeda Yoshihiro
- Tamby Jean-Francois
- Tan Edgar
- Tashchuk Viktor
- Tasic Nebojsa
- Taskinen Marja-Riitta
- Taurio Jyrki
- Ternouth Ian
- Terzic Ibrahim
- Tesloianu Dan N.
- Tespili Maurizio
- Teufel Edward
- Thakkar Maitreya
- Thew Stephen
- Tirador Louie
- Tissera Nirmali
- Todorov Georgi V.
- Toma Mustafa
- Tomala Tadeusz
- Tomulic Vjekoslav
- Tonnessen Glen
- Torstensson Ingemar
- Toursarkissian Nicole
- Tov Naveh
- Treasure Charles, II
- Tretyakova Tatyana V.
- Trevelyan Jasper
- Triana Miguel A. Urina
- Tricoci Pierluigi
- Troquay Roland PTh
- Trotter Charlene
- Tsai Wei-Chuan
- Tse Hung-Fat
- Tseluyko Vira
- Tumbev Haralin S.
- Tunon Fernandez Jose
- Tunon Jose
- Turgeman Yoav
- Turi Tibor
- Turk Samir
- Tyrenko Vadim V.
- Tzekova Maria L.
- Ueda Yasunori
- Uehara Hiroki
- Ueng Kwo-Chang
- Ungi Imre
- Ural Ertan
- Ushakov Olexiy
- Utsu Noriaki
- Vahula Veiko
- Vakaluyk Ihor
- Valdivielso Pedro
- Valdovinos Pablo Carlos Montenegro
- Valgimigli Marco
- Valiris Janine
- Vallejo Gregorio Sanchez
- Vallejos Julio A.
- Van Der Wal Ruud M. A.
- Van Der Zwaan Coenraad C.
- Van Diepen Sean F. P.
- Van Huysduynen-Monraats Pascalle S. Hooft
- Van Zyl Louis J.
- Vardas Panagiotis
- Vardi Gil
- Vargas Gonzales Rolando J.
- Varleta Paola
- Vatutin Mykola
- Vedere Amarnath
- Vejar Margarita
- Velcheva Elena S.
- Verdel Gerardus J. E.
- Vered Zvi
- Verrier Melanie
- Vervoort Geert
- Vico Marisa L.
- Vida Manuel
- Videbaek Lars
- Vidotti Maria H.
- Vidovich Mladen
- Viergever Eric P.
- Viigimaa Margus
- Vijay Nampalli
- Vijayaraghavan Ram
- Vikman Saila
- Viktorova Inna
- Vincendet Marion
- Violini Roberto
- Vishnevsky Alexander Y.
- Vizel Saul
- Vo Anthony
- Voeller Heinz
- Voevoda Mikhail I.
- Vohra Rakesh
- Vora Kishor
- Voyce Stephen
- Vrolix Mathias C. M.
- Vulic Dusko
- Vuurmans Tycho
- Wada Atsuyuki
- Waider Winfried
- Waisman Gabriel D.
- Waites Jonathon H.
- Wali Andreas
- Walichiewicz Piotr Maria
- Waltenberger Johannes
- Waltman Jonathan
- Wang Jian'An
- Wang Jianzhong
- Wang Jingfeng
- Wattanakit Keattiyoat
- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weissbrodt Matthias
- Welka Stephen
- Welker James
- Wells Terry
- Werner Nikos
- Westbrook Melissa
- Westerhausen Donald, Jr.
- Whitaker Jack
- White Harvey D.
- White Lindsey
- White Matthew
- Wiersma Jacobijne J.
- Wilkins Gerard
- Wilkinson Peter
- Willems Frank F.
- Wilson Matthew D.
- Winkelmann Bernhard
- Wiseman Alan
- Witt Nils
- Wlodarczak Adrian
- Wojewod Pawel
- Wollaert Bart
- Wong Yuk-Ki
- Wongpraparut Nattawut
- Wozniak Julianna
- Wright Scott
- Wu Chun
- Xavier Denis
- Xenakis Mark
- Xu Biao
- Xu Dingli
- Xu Xiping
- Xu Yizhou
- Yagensky Andriy
- Yakushin Sergey
- Yan Andrew Tze-Kay
- Yan Bryan P. Y.
- Yanez Mario
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yerra Shiv Kumar
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Zahger Doron
- Zaidman Cesar J.
- Zainea Mark
- Zaman Azfar
- Zapata Gerardo
- Zdravko Babic
- Zea Nunez Carlos A.
- Zeiher Andreas M.
- Zhang Ruiyan
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Xingsheng
- Zheleznyy Volodymyr
- Zheng Yang
- Zheng Zeqi
- Zhou Yujie
- Zhu Hong
- Zhu Jianhua
- Zirlik Andreas
- Zizka Jiri
- Zobouyan Isabelle
- Zong Wenxia
- Zrazhevsky Konstantin
- Zurakowski Aleksander
- Zuran Ivan
- Zweiker Robert
- Publication venue
- Publication date
- 01/01/2019
- Field of study